Metagenics HPA Essentials 60 tablets

For Healthy Stress Response and Neuroendocrine Function

HPA Essentials has been shown to or may:

• High dose vitamin B5 helps healthy neuroendocrine function in combination with vitamin C for adrenal health: Improves the adrenal gland rhythm - A researched trial of 52 people demonstrated a daily combination of vitamins B1 and B6, and 900 mg ascorbic acid, improved glucocorticoid function of the adrenal glands, and simultaneously normalised the rhythmic activity of the gland.
• Assist metabolism and synthesis of some neurotransmitters.
• Vitamins B1 and B12 help protect from HPA dysfunction and regulate the cortisol clock. Vitamin B1 has been shown to reduce cortisol activity in times of stress, thereby protecting the body against excessive cortisol. Although mecobalamin, the active form of vitamin B12, doesn't increase levels of cortisol in the blood, evidence suggests it helps shift the cortisol secretion peak, helping place the cortisol clock back on schedule.
• B vitamins needed for neurotransmitter synthesis. Vitamin B6 is important due to its function as a coenzyme in the biosynthesis of neurotransmitters GABA, noradrenaline, dopamine and serotonin. Pyridoxal 5-phosphate, (P5P), is the biologically active form of B6. Vitamin B5 is involved in the synthesis of melatonin from serotonin due to its progression to Coenzyme A (CoA), which donates its acetyl group to serotonin to convert to melatonin, which has been shown to have a favourable effect on certain dysphoric mental states such as restlessness, anxiety and depression. Vitamin B5 deficiency is specifically related to decreased adrenal function and biotin deficiency has been shown to contribute to adrenal insufficiency.