Folinic Acid - What’s all the fuss about ?

Pure Innovation Folinic Acid

Also referred to as folic acid, folate, B9 and 5-methyltetrahydrofolate, folinic acid in the active form of folate, the version that is better absorbed and metabolised by your body. Folic acid – seen in many foods and supplements, is a synthethic version, meaning your body has to work that little bit harder to make it useful.

Folinic acid plays a vital role in the metabolism of amino acids (protein groups) and the formation of some key agents that keep the energy cycle moving, produce DNA, support the detoxification pathway and help the body absorb many other important nutrients. 

The role in anxiety

Folate is important in the processes that produce the brain chemicals (neurotransmitters) serotonin, dopamine and melatonin. Problems with folate metabolism have been associated with depression and anxiety due partly to the inadequate production of SAMe. SAMe is an enzyme essential in producing the neurotransmitters mentioned which ensure healthy function of nerves and the brain.

The role in migraine

Folinic acid along with B12 and B6 are vitamins required to metabolise an amino acid called homocysteine. Homocysteine is formed from another amino acid called methionine which is a powerful antioxidant.

High levels of homocysteine in the blood cause problems in the lining of blood vessels which can lead to migraines. Approximately 20% of migraine sufferers get their migraines through blood vessel issues, with the others having many other reasons for their migraine including an inherited tendency, dietary sensitivities, environmental triggers or hormones.

Folinic acid works closely with:

  • Vitamins: B2, B3, B5, B6, B12,
  • Minerals: Copper, iron, magnesium and zinc


There are two folinic acid products available at Natural Chemist:

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